Delft University of Technology Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1 in tumor-associated macrophages
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Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages
Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and increased metastasis formation. Recently, we demonstrated a mechanistic link between mammary tumor-induced IL17-producing γδ T cells, systemic ...
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تاریخ انتشار 2018